Scientific Name: Manis javanica
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Pholidota-> Manidae-> Manis
Summary: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2012] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0035 | 2021.04 | 10X Genomics | Duodenum | Normal | 1482 | Link |
| Vthunter_0036 | 2021.04 | 10X Genomics | Esophagus | Normal | 24581 | Link |
| Vthunter_0037 | 2021.04 | 10X Genomics | Heart | Normal | 12958 | Link |
| Vthunter_0039 | 2021.04 | 10X Genomics | LargeIntestine | Normal | 3328 | Link |
| Vthunter_0040 | 2021.04 | 10X Genomics | Liver | Normal | 5694 | Link |
| Vthunter_0041 | 2021.04 | 10X Genomics | Lung | Normal | 13720 | Link |
| Vthunter_0042 | 2021.04 | 10X Genomics | Spleen | Normal | 3207 | Link |
| Vthunter_0043 | 2021.04 | 10X Genomics | Stomach | Normal | 12485 | Link |
Featureplot of receptors
Expression: Biased expression in skin (RPKM 30.6), esophagus (RPKM 23.7) and 8 other tissues
